N. DAVID CHARKES, M.D.
To the Editor: In a recent letter to the Editor of the ANNALS (1), I stated that Silverstein, Burke, and Cogan had misinterpreted their data concerning the effects of L-triiodothyronine (L-T3) on the 24-hr radioiodine uptake in some of their patients with "hot" thyroid nodules, and I suggested that a fall in the 24-hr epithyroid count probably represents accelerated iodine turnover within an autonomous nodule, that is, a thyrotrophin-like action of L-T3. My conclusions were based upon a study of the 2- and 24-hr uptake values before and after L-T3 in toxic nodular goiter, which my colleagues and I have
CHARKES ND. AUTONOMOUS THYROID NODULES. Ann Intern Med. ;69:405–406. doi: 10.7326/0003-4819-69-2-405
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Published: Ann Intern Med. 1968;69(2):405-406.
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