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Once again drawing on his vast clinical experience and with his usual verve and vigor, Jan Waldenström approaches his favorite topics of the monoclonal and polyclonal gammopathies. After some preliminary definition and exposition of terms, the problems of the biological significance or meaning of human serum M components are entertainingly discussed and the view espoused that such homogeneous proteins are probably 'antibody without antigen.' A group of very interesting patients with myeloma serum proteins and concomitant clinical findings of polyangiitis nodosa are described, and the clinical pictures or laboratory findings adeptly interwoven with comments about other similar cases from the
Monoclonal and Polyclonal Hypergammaglobulinemia. Clinical and Biological Significance.. Ann Intern Med. ;69:647–648. doi: 10.7326/0003-4819-69-3-647_2
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Published: Ann Intern Med. 1968;69(3):647-648.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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