LARRY J. WRIGHT, M.D.; LEWELLYS F. BARKER, M.D.; IRA D. MICKENBERG, M.D.; SHELDON M. WOLFF, M.D., F.A.C.P.
Laboratory-acquired typhus fevers occurred in four patients. Early effective antibiotic therapy in all four and previous vaccination in the two with epidemic typhus resulted in the absence of the rash that is a cardinal sign of naturally occurring typhus fevers. Liver function abnormalities, present in three of the four patients, have been infrequently reported in successfully treated patients but may well be typical of the naturally occurring diseases. The need for the development of more effective vaccines and the attendant risks to laboratory workers are discussed.
WRIGHT LJ, BARKER LF, MICKENBERG ID, WOLFF SM. Laboratory-Acquired Typhus Fevers. Ann Intern Med. 1968;69:731–738. doi: 10.7326/0003-4819-69-4-731
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Published: Ann Intern Med. 1968;69(4):731-738.
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