DAVID RIFKIND, PH.D., M.D., F.A.C.P.
Cytomegalovirus infection, which is usually subclinical, occurs in approximately 6% of women during pregnancy (1) and may result in congenital infection in up to 1 to 2% of the newborn (1, 2). Only a minority of these newborn manifest the classical, acute, fatal cytomegalic inclusion disease with hepatosplenomegaly, hemolytic anemia, jaundice, thrombocytopenic purpura, and central nervous system damage. In others the infection produces various combinations of hepatoslpenomegaly, abnormal liver function tests, microscephaly, and mental and motor retardation (2, 3). The total frequency of disease after congenital infection and its ultimate course remain to be established.
Postnatally acquired cytomegalovirus infection occurs
RIFKIND D. Cytomegalovirus Mononucleosis. Ann Intern Med. ;69:842–843. doi: 10.7326/0003-4819-69-4-842
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Published: Ann Intern Med. 1968;69(4):842-843.
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