WINSTON WARR, M.D.; JOSEPH H. BATES, M.D., F.A.C.P.; ALICE STONE
Cryptococcus neoformans was cultured from the sputum, bronchial washings, or pleural fluid of 17 patients, 9 of whom were thought to have cryptococcal pulmonary disease. Of the nine, six were not treated with amphotericin B, and all but one are now culturally negative. Seven culturally positive patients had other diseases such as chronic bronchitis, tuberculosis, or carcinoma that seemed to account for the clinical picture. None of these were treated with amphotericin B, and all are either well or have died from an unrelated illness. The fluorescent antibody test for detection of cryptococcal antibodies was positive in 8 of 15 patients but was not helpful in evaluating presence or absence of cryptococcal disease. Correct management of these patients must await the development of a more thorough understanding of the prevalence and significance of C. neoformans cultured from the lung.
WARR W, BATES JH, STONE A. The Spectrum of Pulmonary Cryptococcosis. Ann Intern Med. ;69:1109–1116. doi: 10.7326/0003-4819-69-6-1109
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Published: Ann Intern Med. 1968;69(6):1109-1116.
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