DAVID GOLDE, M.D.; WALLACE EPSTEIN, M.D., F.A.C.P.
The serum of a patient with rapidly progressive glomerulonephritis associated with mixed cryoglobulins showed sustained high levels of rheumatoid factors. Immunoglobulin (Ig) G, M, and beta1C-globulin were demonstrated in the involved glomeruli by the fluorescent antibody technique. Treatment of the patient with prednisone and chlorambucil was associated with a falling serum creatinine but with no change in circulating cryoglobulins. The patient died of an intracerebral hemorrhage.
GOLDE D, EPSTEIN W. Mixed Cryoglobulins and Glomerulonephritis. Ann Intern Med. ;69:1221–1228. doi: 10.7326/0003-4819-69-6-1221
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Published: Ann Intern Med. 1968;69(6):1221-1228.
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