WILLIAM C. DAVIS, PH.D.; STEVEN D. DOUGLAS, M.D.; H. HUGH FUDENBERG, M.D.
In vitro studies of neutrophils from a young man with the clinical manifestations of chronic granulomatous disease of childhood revealed a selective inability to kill opsonized staphylococci. The defect appeared to be nonfamilial, since neutrophils from his parents demonstrated normal bactericidal capacity in vitro. The patient had no detectable immunoglobulin deficiencies; his serum, however, lacked specific antibodies to staphylococcal products (F and S antigens of leukocidin). After immunization with staphylococcal toxoids he showed a rise in serum antileukocidin titers and clinical improvement.
WILLIAM C. DAVIS, STEVEN D. DOUGLAS, H. HUGH FUDENBERG. A Selective Neutrophil Dysfunction Syndrome: Impaired Killing of Staphylococci. Ann Intern Med. 1968;69:1237–1244. doi: 10.7326/0003-4819-69-6-1237
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Published: Ann Intern Med. 1968;69(6):1237-1244.
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