ERIC REISS, M.D.
The development of radioimmunoassay techniques for measuring plasma concentration of peptide hormone has made possible many important conceptual advances in clinical endocrinology. Adaptation of these methods to
parathyroid hormone (PTH) has proved difficult, but recent progress in several laboratories provides hope that the assay of PTH will be clinically useful in the foreseeable future (1-3).
The following problems have delayed progress:  it has been difficult to produce antisera with sufficiently high affinity for PTH to make them suitable for assay work;  bovine and human PTH probably differ antigenically;  hyperfunctioning parathyroid glands may secrete not only one but
REISS E. Measurement of Parathyroid Hormone. Ann Intern Med. 1968;69:1325–1326. doi: 10.7326/0003-4819-69-6-1325
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Published: Ann Intern Med. 1968;69(6):1325-1326.
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