ANDREW CORONATO, M.D.; ALLAN B. COHEN, M.D.
The first reported case of lactic acidosis secondary to severe anemia with complete and immediate reversal of the acidosis after transfusion with packed red blood cells is described in a patient with pernicious anemia. Experimental evidence that severe anemia can cause widespread tissue hypoxia is cited. The pathophysiology, causal classification, and diagnosis of lactic acidosis are reviewed.
CORONATO A, COHEN AB. Lactic Acidosis Secondary to Pernicious Anemia. Ann Intern Med. ;70:77–80. doi: 10.7326/0003-4819-70-1-77
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Published: Ann Intern Med. 1969;70(1):77-80.
Endocrine and Metabolism, Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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