ZBIGNIEW A. ZAWADZKI, M.D.; THOMAS G. BENEDEK, M.D., F.A.C.P.; DANIEL EIN, M.D.; JOHN M. EASTON, M.D.
The eighth known case of heavy-chain disease is reported. Immunochemical studies of abnormal Fc fragment gamma-G3 protein and detailed morphologic, chromosomal, and electron microscopic observations are included. This patient, a 51-year-old negro man, is unique in that symptoms of heavy-chain disease began 9 years after the onset of rheumatoid arthritis. Pathologic studies failed to demonstrate malignant lymphoma.
Possible pathogenetic relationships between monoclonal paraproteinemias and rheumatoid arthritis are discussed.
ZBIGNIEW A. ZAWADZKI, THOMAS G. BENEDEK, DANIEL EIN, JOHN M. EASTON. Rheumatoid Arthritis Terminating in Heavy-Chain Disease. Ann Intern Med. 1969;70:335–347. doi: 10.7326/0003-4819-70-2-335
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Published: Ann Intern Med. 1969;70(2):335-347.
Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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