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The phenomenon of immunological tolerance has continued to occupy a central position in the thinking and activities of immunologists and in the hopes of those concerned with therapeutic organ replacement since its existence was first placed upon a sound experimental basis in 1953. Although confidence in the potentialities of immuno-suppression by drugs has been greatly bolstered by knowledge of the potency of antilymphocyte serum (ALS) and its apparently relatively trivial adverse effects, the induction of specific immunologic tolerance in respect of donor tissue transplantation antigens remains unassailed as the transplanter's goal.
Dr. Hraba, one of the founder members of the
Mechanism and Role of Immunological Tolerance.. Ann Intern Med. 1969;70:661. doi: 10.7326/0003-4819-70-3-661_1
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Published: Ann Intern Med. 1969;70(3):661.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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