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Anaphylactoid edema produced in experimental animals by the injection of heterologous proteins, dextrans, compound 48/80, polymyin, and other agents has proved a valuable model for studying drugs and other factors that initiate, influence, and impede the release of vasoactive mediators. Modifications of the basic edema-producing response by altering the route of administration or by combination with other agents such as dihydrotachysterol, ferric dextran, and epinephrine produce the qualitatively different but related responses of mastocalcergy, mastocaliphylaxis, acute conditioned necrosis, and thrombohemorrhagic phenomenon. Although these conditions are produced primarily in the rat, the obvious parallel with urticaria, angioedema, and some forms
Anaphylactoid Edema.. Ann Intern Med. 1969;70:872–873. doi: 10.7326/0003-4819-70-4-872_2
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Published: Ann Intern Med. 1969;70(4):872-873.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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