GÖRAN KRONVALL, M.D.; RALPH C. WILLIAMS JR., M.D.
Some recent findings documenting exciting although rather anomalous short circuits in current biological thought have prompted us to reemphasize the obvious fact that many diverse biological processes are interrelated—sometimes in unexpected and exciting ways. We have chosen four examples to indicate the well-known experience that when two seemingly incoordinated or widely disparate fields of investigation cross, important biological phenomena may be perceived.
The first example of an interesting biological short circuit is the recent demonstration by Gewurz and co-workers (1, 2) that purified lipopolysaccharide can react directly with components of complement, apparently without benefit of discernible antibody. This group's idea
KRONVALL G, WILLIAMS RC. Immunologic "Short Circuits". Ann Intern Med. ;70:1043–1045. doi: 10.7326/0003-4819-70-5-1043
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Published: Ann Intern Med. 1969;70(5):1043-1045.
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