GERALD BURKE, M.D., C.M., F.A.C.P
The role of the long-acting thyroid stimulator (LATS) in the development, or progression, or both, of infiltrative ophthalmopathy continues to be the subject of considerable speculation. Because resolution of this putative relationship may have considerable therapeutic import, the evidence for and against such a causal role for LATS bears close scrutiny.
The frequency with which LATS has been found on assay of whole serum in Graves' disease has varied markedly (1). However, the thesis that the stimulator is present in all instances of hyperthyroidism of Graves' disease and is therefore a causative factor is supported by the demonstration of LATS
BURKE G. Long-Acting Thyroid Stimulator and Exophthalmos. Ann Intern Med. ;70:1045–1046. doi: 10.7326/0003-4819-70-5-1045
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Published: Ann Intern Med. 1969;70(5):1045-1046.
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