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In 1835 my great country-fellow, J. J. Berzelius, made the conception of "catalysis" as an ability inherent in some organic and inorganic substances to start and maintain chemical reactions by their mere presence in a solution and founded his statement on quantitative analyses of different materials. Further development was then for a long time retarded by the false theory of a "vital force" being the cause of the reactions in living cells.
Modern time begins with Buchner's discovery in 1897 of the cell-free fermentation. The chemical nature of the catalysts ("enzymes," in "in yeast," Kühne), however, remained unknown for still
Hugo Theorell. ACP Honorary Fellowship Lecture: Enzyme Research in Past and Present Time.. Ann Intern Med. 1969;70:1059–1060. doi: 10.7326/0003-4819-70-5-1059_4
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Published: Ann Intern Med. 1969;70(5):1059-1060.
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