J. William Cox, M.D., F.A.C.P.; Bill D. Stout, M.D.; Leslie Wiener, M.D.
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Clinical and metabolic effects of propranolol (4.6 to 10.3 mg/kg/day) and phenoxybenzamine hydrochloride (0.44 to 0.82 mg/kg/day) administered for an average of 71 days were studied in eight hyperthyroid patients. Body weight, oxygen consumption, kinemometric measurements of the Achilles reflex, serum lipids (cholesterol, triglycerides, and phopholipids) were studied. Common thyroid function tests including protein-bound iodine, 131I-uptake, resin triiodothyronine uptake test, and 131I scan of the thyroid gland were measured before and after treatment. Five normal male subjects (mean age, 22 years) given propranolol (3.2 to 5.0 mg/kg/day) and phenoxybenzamine hydrochloride (0.3 to 0.47 mg/kg/day) served as controls for oxygen consumption
Cox JW, Stout BD, Wiener L. Combined Alpha- and Beta-Sympathetic Blockade in Hyperthyroidism: Clinical and Metabolic Effects.. Ann Intern Med. ;70:1061. doi: 10.7326/0003-4819-70-5-1061_2
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Published: Ann Intern Med. 1969;70(5):1061.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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