Wilbert S. Aronow, M.D.; Marvin A. Kaplan, M.D.
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The combination of sublingual isosorbide dinitrate, 5 mg, plus oral propranolol, 40 mg given four times daily, was evaluated in a double-blind study in comparison with an oral plus a sublingual placebo in 23 patients with angina pectoris. Both of these medications were given in two successive 6-week periods. Eleven patients received the drugs, and 12 received the placebos in the first 6-week period. Each patient was exercised on a bicycle ergometer at a load of 60 w until the onset of angina twice on the last 3 days of each 6-week period 1½ hr after receiving medications given 4
Aronow WS, Kaplan MA. Propranolol Plus Isosorbide Dinitrate in Angina Pectoris.. Ann Intern Med. ;70:1072–1073. doi: 10.7326/0003-4819-70-5-1072_3
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Published: Ann Intern Med. 1969;70(5):1072-1073.
Cardiology, Coronary Heart Disease, Coronary Risk Factors, Hypertension, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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