Frank E. Trobaugh Jr., M.D., F.A.C.P.
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When isogenic bone marrow cells are injected intravenously into a lethally irradiated recipient, the hematopoietic stem cells seed in the empty hematopoietic space and proliferate, producing functioning hematopoietic tissue. The repopulating potential of such transplanted hematopoietic tissue is directly related to the stem-cell content of the donor graft. These stem cells constitute only a small fraction of the cellular population of the marrow, and their morphology has continued to elude all investigators. Recently, however, it has been possible to study their relative numbers and their differentiating capacity and thus to investigate the dynamic processes of hematopoietic proliferation and differentiation.
Trobaugh FE. The Dynamics of Hematopoietic Repopulation.. Ann Intern Med. ;70:1087. doi: 10.7326/0003-4819-70-5-1087_1
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Published: Ann Intern Med. 1969;70(5):1087.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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