Edward P. Cohen, M.D.
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Previously, we reported that a ribonucleic acid (RNA) extract from the spleens of immunized mice converted in vitro a small proportion of nonimmune spleen cells to form specific antibody (J. Immun. 95: 583, 1965). Miller and associates (J. Exp. Med. 128: 801, 1968) demonstrated that the cells responsible for antibody formation when thymectomized mice were reconstituted with intact thymocytes originated in the host and were not thymus-derived cells. Control mice not given thymocytes failed to produce antibody. This suggested that a substance was transferred from thymus-derived cells to host cells. To determine if such a mediator might be detected in
Cohen EP. Conversion of Nonimmune Cells to Antibody-Forming Cells with an RNA-Extract from the Thymus.. Ann Intern Med. 1969;70:1088. doi: 10.7326/0003-4819-70-5-1088_1
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Published: Ann Intern Med. 1969;70(5):1088.
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