George J. Friou, M.D., F.A.C.P.; Takeshi Tojo, M.D.
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In certain patients antinuclear antibodies are "benign" while in systemic lupus with nephritis they are involved in production of nephritis by deposition as immune complexes with nuclear antigens and complement. We have found that, in the former, complement-fixing activity of such antibodies is low, even though present in large amounts, while in lupus nephritis complement-fixing activity is high.
Relative complement-fixing activity of antinuclear antibodies was determined by comparing titers in the complement fluorescent technique with titers by conventional antinuclear antibodies. Patients included active lupus nephritis (15), other systemic lupus erythematosus patients (26), rheumatic arthritis (20), chronic active hepatitis (7), and
Friou GJ, Tojo T. "Benign" Versus "Malignant" Antinuclear Antibodies.. Ann Intern Med. ;70:1088. doi: 10.7326/0003-4819-70-5-1088_3
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Published: Ann Intern Med. 1969;70(5):1088.
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