Nicholas A. Kefalides, M.D.; Berta Denduchis, Ph.D.
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Previous studies demonstrated the cross antigenicity between endothelial and epithelial basement membranes. In the present study we have isolated and characterized chemically and immunologically the antigenic components of basement membranes from the glomerulus, alveolus, and lens capsule. The basement membranes were solubilized by reduction and alkylation and antisera prepared in rabbits. On immunodiffusion two precipitin lines of identity form when antiserum to either reduced and alkylated glomerulus or lens-capsule basement membranes is reacted with both antigens. Reduced and alkylated alveolus basement membrane reacts similarly with both antisera. Upon fractionation of the basement membranes two antigenic components are obtained. One is
Kefalides NA, Denduchis B. Structural and Immunologic Aspects of Vascular and Capsular Basement Membranes.. Ann Intern Med. ;70:1088–1089. doi: 10.7326/0003-4819-70-5-1088_4
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Published: Ann Intern Med. 1969;70(5):1088-1089.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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