E. J. Bardana Jr., M.D.; G. A. Porter, M.D.; G. A. Jacobsen, B.S.; R. T. Gourley, M.D.; B. Pirofsky, M.D.
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Nineteen patients with steroid-resistant lupus 1 nephritis and nephrotic syndrome secondary to membranous glomerulonephritis and proliferative glomerulonephritis were treated with sustained low-dose azathioprine (2.0 mg/kg body weight/day) and prednisone (5 to 15 mg/day) for up to 14 months. Serial determinations were measured to assess:  functional response;  criteria for patient selection; and  relationship of renal functional improvement with changes in the immune apparatus. Renal function was measured by creatinine clearance, albumin-to-globulin ratio, quantitation and selectivity of urinary protein, cholesterol, and renal biopsy. Cellular immunity was studied by skin tests with mumps, Candida, or 2,4-dinitrochlorobenzene antigens. Humoral antibody response
Bardana EJ, Porter GA, Jacobsen GA, Gourley RT, Pirofsky B. Immunosuppression in Steroid-Resistant Nephropathy.. Ann Intern Med. ;70:1093. doi: 10.7326/0003-4819-70-5-1093_1
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Published: Ann Intern Med. 1969;70(5):1093.
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