G. S. Berenson, M.D., F.A.C.P.; E. R. Dalferes Jr.; H. Ruiz; F. A. Dugan, M.D.; B. Radhakrishnamurthy, Ph.D.
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Chemical changes leading to diabetic microangiopathy are of considerable interest. Although poorly understood, from histochemical studies the changes are primarily attributed to glycoproteins. The acid mucopolysaccharides have been stated to occur in insignificant proportions.
These studies evaluate mucopolysaccharide composition of kidneys from 16 diabetic patients and 3 individuals without renal disease or diabetes. The kidney tissues were divided into cortical and medullary portions, and mucopolysaccharides were isolated by proteolytic digestion, deproteinization with trichloroacetic acid, and precipitation with ethanol. The mucopolysaccharide preparations were fractionated on Dowex 1-2X C1-columns and the fractions extensively analyzed to quantitate the individual mucopolysaccharides. The contents of
Berenson GS, Dalferes ER, Ruiz H, Dugan FA, Radhakrishnamurthy B. Acid Mucopolysaccharide Changes in Diabetic Kidneys.. Ann Intern Med. ;70:1093. doi: 10.7326/0003-4819-70-5-1093_2
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Published: Ann Intern Med. 1969;70(5):1093.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Nephrology.
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