Gerhard Freund, M.D., F.A.C.P.
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Progress in alcoholism research has been slow because of the lack of a suitable animal model of the alcohol withdrawal syndrome. This is the first description of an alcohol withdrawal syndrome induced in animals drinking alcohol. A liquid diet containing 40% calories as ethanol was the only source of calories and fluids for 20 adult female ICR mice for 3 months. The mice lost weight, from 27 to 30 g at the beginning of the experiment to 20 to 30 g at the time of withdrawal. During the 10 days before ethanol withdrawal all mice that developed a withdrawal reaction
Freund G. Alcohol Withdrawal Syndrome in Mice.. Ann Intern Med. ;70:1101. doi: 10.7326/0003-4819-70-5-1101_1
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Published: Ann Intern Med. 1969;70(5):1101.
Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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