Charles P. Perlia, M.D.; David Edelberg, M.D.
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Mithramycin, an antibiotic antitumor agent, is most useful in the treatment of embryonal-cell carcinoma of the testes. It has been noted, among other side effects, to produce hypocalcemia, even in patients with normal initial serum calcium levels. Because of this effect, the drug was investigated in patients with hypercalcemia of various causes.
Fourteen patients with hypercalcemia due to malignant disease affecting the osseous system and one patient with hypercalcemia due to primary hyperparathyroidism have been treated to date. It has been found that mithramycin is indeed effective in reducing the elevated serum and urinary calcium levels. The dose necessary to
Perlia CP, Edelberg D. Mitramycin Treatment of Hypercalcemia.. Ann Intern Med. ;70:1103. doi: 10.7326/0003-4819-70-5-1103_1
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Published: Ann Intern Med. 1969;70(5):1103.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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