Stanley R. Platman, M.D.; Leslie Baer, M.D.; Ronald R. Fieve, M.D.
This content is PDF only. Please click on the PDF icon to access.
Evidence has accumulated for 70 years suggesting the relationship between electrolyte and fluid balance and the cyclic effective disorders. Recent studies in humans with affective disorders, utilizing isotope dilution techniques and body compartment measurements, have shown changes in sodium and body fluids which correlate with behavioral changes. This relationship is strengthened by the therapeutic efficiency of lithium in mania.
Body compartment measurements and fluid balance have been studied in the mood changes of manic-depressive disease. The effects of lithium have been evaluated in those patients with or without therapeutic response. The mechanisms for abnormalities in sodium retention and fluid redistribution
Platman SR, Baer L, Fieve RR. An Investigation of Electrolyte and Fluid Distribution in the Affective Disorders.. Ann Intern Med. 1969;70:1103. doi: 10.7326/0003-4819-70-5-1103_2
Download citation file:
Published: Ann Intern Med. 1969;70(5):1103.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use