Carlo H. Tamburro, M.D.; Carroll M. Leevy, M.D., F.A.C.P.
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Patients with delirium tremens (DTs) exhibit reduced cerebral oxidative metabolism reflected in an increase of spinal fluid lactate (Clin. Res. 16: 353, 1968). Studies were undertaken to determine the diagnostic and therapeutic significance of this finding in withdrawal syndromes of the alcoholic. Lactate, pyruvate, thiamine, magnesium, and oxygen were measured in blood and spinal fluid before, during, and after various treatment regimens in 15 nonalcoholics with and without delirium and 45 alcoholics (10 with normal mentation, 6 with psychiatric disease not due to alcoholism, 8 with early-phase DTs, 12 with full-blown DTs, and 9 in recovery-phase DTs). Nonalcoholics and alcoholics
Tamburro CH, Leevy CM. Lactate Accumulation in Withdrawal Syndromes of the Alcoholic.. Ann Intern Med. ;70:1104–1105. doi: 10.7326/0003-4819-70-5-1104_3
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Published: Ann Intern Med. 1969;70(5):1104-1105.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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