Herbert Savel, M.D.
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The induction of lymphocyte transformation by various antigens has been shown to be a direct reflection of the degree of lymphocytic or delayedtype immunity in the host. Since specific lymphocyte immunity has been shown to effect regression of transplanted animal tumors, the degree of tumordirected lymphocyte immunity was studied in human cancer. The degree of lymphocyte transformation induced by saline extracts of autologous tumors was determined in 44 patients with cancer. Cultures of peripheral blood lymphocytes were incubated in duplicate with cell-free extracts of autologous tumors (in concentration of 1 to 300 mg protein/ml) and the degree of stimulation determined
Savel H. The Effect of Human Tumor Extracts Upon Autologous Peripheral Blood Lymphocytes.. Ann Intern Med. ;70:1106. doi: 10.7326/0003-4819-70-5-1106_2
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Published: Ann Intern Med. 1969;70(5):1106.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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