JOHN F. WILLIAMS JR., M.D., F.A.C.P.
In 1960 Farah and Tuttle (1) reported that crystalline glucagon exerted positive inotropic and chronotropic effects on isolated hearts of the dog, the rat, the guinea pig, and the cat. Surprisingly there was little further interest in these potentially useful actions until recently. In the past few months a number of papers have substantiated the early observations of Farah and Tuttle and expanded considerably our knowledge of the cardiovascular effects of glucagon as well as the mechanisms by which these effects are produced. In addition, studies of the cardiovascular actions recently have been extended to man, and reports have appeared
WILLIAMS JF. Glucagon and the Cardiovascular System. Ann Intern Med. ;71:419–423. doi: 10.7326/0003-4819-71-2-419
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Published: Ann Intern Med. 1969;71(2):419-423.
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