JOEL S. KARLINER, M.D.
To the Editor: There is a factual error in the otherwise excellent report of Wolfe, Reidenberg, and Vispo on propoxyphene (Darvon®) addiction and withdrawal, (Ann. Intern. Med. 70: 773, 1969). In the discussion section of their paper the authors state that only a ". . . single reported fatality . . ." has resulted from propoxyphene (Darvon®) overdose. There are at least three other well-documented fatal cases in the literature (1-3) and mention of a fourth (4), aside from the report cited by the authors (5).
In one case the fatal ingestion of 2,300 mg of propoxyphene (2), an amount
KARLINER JS. PROPOXYPHENE TOXICITY. Ann Intern Med. 1969;71:428. doi: 10.7326/0003-4819-71-2-428_1
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Published: Ann Intern Med. 1969;71(2):428.
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