RICHARD W. HYDE, M.D.; ARON B. FISHER, M.D.
To the Editor: Dr. Petty's recent editorial note, "Misunderstanding Concerning the Proper Clinical Use of Oxygen," gives sound advice for the application of oxygen therapy in most clinical situations (1). However, the plea for the prolonged use of oxygen concentrations as high as 100% in patients with profound respiratory distress due to hypoxemia requires amplification. Many authors have pointed out that the administration of 100% oxygen for periods in excess of 24 hr will almost inevitably lead to progressive pulmonary insufficiency, severe hypoxia, and death (2). An increasing number of reports are being published describing this course of events in
HYDE RW, FISHER AB. OXYGEN THERAPY. Ann Intern Med. ;71:665–667. doi: 10.7326/0003-4819-71-3-665
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Published: Ann Intern Med. 1969;71(3):665-667.
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