BEVRA H. HAHN, M.D.; JOHN H. YARDLEY, M.D.; MARY BETTY STEVENS, M.D., F.A.C.P.
Six patients with systemic lupus erythematosus (SLE) and periarticular subcutaneous nodules are described. The nodules were biopsied in three patients. Each specimen was histologically typical of the well-developed "rheumatoid" nodule. The features of SLE in these patients included fever, constitutional symptoms, polyarthritis, skin rash, serositis, glomerulonephritis, anemia, and leukopenia. All had lupus erythematosus cells, antinuclear antibodies, and reduced serum complement. The latex test was negative in three patients and only transiently positive in the other three. When present, the subcutaneous nodule was invariably associated with clinically active SLE. In the patient with polyarthritis the presence of periarticular subcutaneous nodules may be a hallmark of SLE as well as rheumatoid arthritis.
BEVRA H. HAHN, JOHN H. YARDLEY, MARY BETTY STEVENS. "Rheumatoid" Nodules in Systemic Lupus Erythematosus. Ann Intern Med. 1970;72:49–58. doi: 10.7326/0003-4819-72-1-49
Download citation file:
Published: Ann Intern Med. 1970;72(1):49-58.
Lupus Erythematosus, Rheumatoid Arthritis, Rheumatology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use