GORDON H. WILLIAMS, M.D.; LESLIE I. ROSE, M.D.; ROBERT G. DLUHY, M.D.; DONALD MCCAUGHN, M.D.; PAUL I. JAGGER, M.D.; ROGER B. HICKLER, M.D.; DAVID P. LAULER, M.D.
The responsiveness of the renin aldosterone system to acute stimulation was determined in 16 patients with essential hypertension and 12 normotensive volunteers. All patients were studied under identical metabolic balance conditions with identical stimuli applied. Acute volume depletion, whether accomplished by venous hemorrhage or diuresis, significantly increased plasma renin activity in 12 out of 16 hypertensive patients and in all normal individuals. In contrast, whereas all normotensive individuals increased aldosterone secretion above base line, only one hypertensive subject exhibited a significant increase in aldosterone secretion. However, both normotensive and hypertensive individuals had indistinguishable aldosterone secretory response to adrenocorticotrophic hormone infusion, indicating an intact aldosterone biosynthetic capacity in the hypertensive subjects. These results suggest a defect in the interaction of angiotensin-II with the adrenal cortex in a certain number of patients with alleged essential hypertension.
WILLIAMS GH, ROSE LI, DLUHY RG, MCCAUGHN D, JAGGER PI, HICKLER RB, et al. Abnormal Responsiveness of the Renin Aldosterone System to Acute Stimulation in Patients with Essential Hypertension. Ann Intern Med. ;72:317–326. doi: 10.7326/0003-4819-72-3-317
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Published: Ann Intern Med. 1970;72(3):317-326.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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