KEVIN P. GLYNN, M.D.; ANTHONY F. CAFARO, M.D.; CURTIS W. FOWLER, M.D.; WILLIAM W. STEAD, M.D.
Para-aminosalicylic acid (PAS) in serum has been shown by in vivo and in vitro studies to induce false elevations in serum glutamic-oxalacetic transaminase (SGOT) level as determined by the colorimetric method commonly used in automated analyzers. This does not appear to reflect any hepatic injury, and no changes have been found in SGOT levels determined by the specific reduced nicotinamide adenine dinucleotide (NADH)-linked method of Karmen, or found in serum glutamic-pyruvic transaminase (SGPT), or in serum lactic acid dehydrogenase (LDH) levels. As the use of multichannel analyzers becomes more widespread more reactions of this type will be observed in patients receiving other drugs.
GLYNN KP, CAFARO AF, FOWLER CW, STEAD WW. False Elevations of Serum Glutamic-Oxalacetic Transaminase Due to Para-Aminosalicylic Acid. Ann Intern Med. 1970;72:525–527. doi: 10.7326/0003-4819-72-4-525
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Published: Ann Intern Med. 1970;72(4):525-527.
Emergency Medicine, Gastroenterology/Hepatology, Liver Disease.
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