JOHN D. SCHMALE, M.D.
Serology has long been used to identify inapparent infections or infections due to organisms not easily or conveniently cultured. Thus, virologic diagnosis uses complement-fixation or hemagglutination-inhibition reactions, and syphillis serology relies on flocculation and indirect fluorescent antibody testing.
The use of serology in detection of gonorrhea has a different basis because in most gonococcal infections the organism can readily be cultured on Thayer-Martin medium (the possible exception being in gonococcal arthritis). Serology in gonorrhea is not so much needed as a diagnostic test but for epidemiological screening. At present, the epidemiological study of gonorrhea is difficult because of the short
SCHMALE JD. Serologic Detection of Gonorrhea. Ann Intern Med. ;72:593–595. doi: 10.7326/0003-4819-72-4-593_2
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Published: Ann Intern Med. 1970;72(4):593-595.
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