Autoantibodies against antigens in tissues, blood, and secretions have been found in patients with so many diverse diseases that their pathogenetic significance has been very hard to assess. Ten years ago the discovery of a new autoantibody in a disease was enough to identify the disease as autoimmune in origin. Today each such discovery is greeted with skepticism. Last year Whittingham and associates (1) reported the frequency of nine autoimmune or isoimmune antibodies in 652 healthy subjects. Although such antibodies were found infrequently in children, they occurred more often with increasing age. Thirty-five percent of subjects over 60 years old
Autoantibodies in Healthy Subjects. Ann Intern Med. ;72:596–597. doi: 10.7326/0003-4819-72-4-596
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Published: Ann Intern Med. 1970;72(4):596-597.
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