RAMON M. FUSARO, M.D., PH.D.
To the editor: In their article "Immunologic Reactivity in Patients with Leprosy," Sheagren and associates (1) report that "Levels of IgG and IgA immunoglobulins were increased in lepromatous disease while IgM levels were normal in all groups." This statement conflicts with recent findings (2, 3) in which patients with lepromatous and tuberculoid types of leprosy can be distinguished by the concentrations of their serum immunoglobulins. In lepromatous leprosy both IgG and IgM levels are significantly elevated, whereas in the tuberculoid type IgG and IgA levels are elevated. IgA levels are normal in lepromatous type, and IgM levels are normal in
FUSARO RM. Immunologic Reactivity in Leprosy. Ann Intern Med. ;72:602. doi: 10.7326/0003-4819-72-4-602_1
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Published: Ann Intern Med. 1970;72(4):602.
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