DONALD L. GORDON, M.D.
To the editor: I have come to a different conclusion than the author, Robert M. Boyar, after reading his article, "The Effect of Clomiphene Citrate in Anosmic-Hypogonadotrophism" (Ann Intern Med 71:1127, 1969). The patient was presented as a case of anosmia and hypogonadotrophic eunuchoidism due to defective pituitary activation by the hypothalamic releasing factors for luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This diagnosis seems very dubious since the patient had normal levels of plasma LH and FSH. Alternatively, the lack of secondary sex characteristics, the immature seminiferous tubules and Leydig cells, the very low base-line plasma testosterone level, and
GORDON DL. Anosmic-Hypogonadotrophism?. Ann Intern Med. ;72:602–603. doi: 10.7326/0003-4819-72-4-602_2
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Published: Ann Intern Med. 1970;72(4):602-603.
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