ROGER K. LARSON, M.D., F.A.C.P.; MARTIN L. BARMAN, M.D.; FRIEDRICH KUEPPERS, M.D.; H. HUGH FUDENBERG, M.D.
The prevalence of abnormalities of pulmonary function among 156 relatives of 61 patients with chronic obstructive pulmonary disease was found to be significantly higher than the prevalence in a control group of their spouses. No relationship of this increased familial prevalence to alpha1-antitrypsin deficiency could be demonstrated. This provides further evidence that at least some chronic obstructive pulmonary disease may be genetically determined and that this may be independent of alpha1-antitrypsin deficiency. Heredity and smoking probably contribute about equally to the likelihood of developing chronic obstructive pulmonary disease.
LARSON RK, BARMAN ML, KUEPPERS F, FUDENBERG HH. Genetic and Environmental Determinants of Chronic Obstructive Pulmonary Disease. Ann Intern Med. ;72:627–631. doi: 10.7326/0003-4819-72-5-627
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Published: Ann Intern Med. 1970;72(5):627-631.
Chronic Obstructive Airway Disease, Pulmonary/Critical Care.
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