MATTHEW C. RIDDLE, M.D.; THEODORE B. SCHWARTZ, M.D.
The similarity between signs and symptoms of hyperthyroidism and of excessive adrenergic activity is well known. Though it is clear that the thyroid hormones have many direct metabolic effects, the balance of experimental evidence supports the idea that increased tissue sensitivity to catecholamines also contributes much to the clinical picture of hyperthyroidism (1). The well-known studies of Brewster, Isaacs, and Osgood (2) showed that epidural blockade inhibited many, particularly cardiovascular, effects of thyroid feeding in dogs, presumably by eliminating sympathetic nervous activity. The idea of using sympatholytic agents as therapy for thyrotoxicosis in man followed naturally from this observation. Spinal
RIDDLE MC, SCHWARTZ TB. New Tactics for Hyperthyroidism: Sympathetic Blockade. Ann Intern Med. ;72:749–751. doi: 10.7326/0003-4819-72-5-749
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Published: Ann Intern Med. 1970;72(5):749-751.
Endocrine and Metabolism, Thyroid Disorders.
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