Carl V. Moore, M.D., F.A.C.P.
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Splenic function is only partially understood but includes:
 Role in blood formation. In fetal life, in diseases characterized by extramedullary hematopoiesis, and constantly in certain animals, all cellular elements of the blood are made in the spleen.
 Role in sequestration and destruction of blood cells—
abnormal cells in a normally functioning spleen versus normal cells in an abnormally functioning spleen. Metabolic changes incident to sequestration, as well as phagocytosis, probably contribute to the destruction.
 Role in antibody production. Three immunocompetent cells are produced: plasma cells, lymphocytes, and reticulum cells. In immunologic disorders the antibodies they produce may
Carl V. Moore. The John Phillips Memorial Lecture: Dyssplenism and the Organ of Mystery.. Ann Intern Med. 1970;72:775. doi: 10.7326/0003-4819-72-5-775_3
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Published: Ann Intern Med. 1970;72(5):775.
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