L. Gould, M.D., F.A.C.P.; R. F. Gomprecht, M.D., F.A.C.P.; M. Zahir, M.D.
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The beneficial effect of intravenously administered phentolamine on digitalis-induced cardiac arrhythmias has been recently demonstrated in dogs. Intravenous phentolamine has also proved valuable in reducing or abolishing digitalis- or non-digitalis-induced ventricular premature contractions in man. In addition, recent reports indicate that the drug increases myocardial contractility. These considerations prompted a clinical trial involving the oral administration of phentolamine to 20 patients with frequent ventricular premature contractions of long duration. Fifty milligrams of phentolamine were given four times a day for 2 days. If there was no effect on the contractions the dose was raised to 75 mg for 2 days
Gould L, Gomprecht RF, Zahir M. Oral Phentolamine for Treatment of Ventricular Premature Contractions.. Ann Intern Med. ;72:779. doi: 10.7326/0003-4819-72-5-779_1
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Published: Ann Intern Med. 1970;72(5):779.
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