Robert H. Seller, M.D., F.A.C.P.; Martin Neff, M.D.; Saul Mendelssohn, M.D.; Kwan E. Kim, M.D., (Associate); Charles Swartz, M.D., F.A.C.P.
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This study was undertaken to define the mechanism of the antiarrhythmic effect of magnesium sulfate in digitalis toxicity. We recently reported that hypomagnesemia facilitates the development of arrhythmias due to digitalis toxicity and these are terminated promptly by intravenous magnesium sulfate. Digitalis causes an egress of potassium from the myocardium. This myocardial potassium loss underlies the development of arrmythmias. In 16 dogs potassium and magnesium were measured in samples obtained simultaneously from the femoral artery and coronary sinus twice in a control period and at 2-min intervals after the administration of 1 mg acetylstrophanthidin into the right atrium. This was
Seller RH, Neff M, Mendelssohn S, Kim KE, Swartz C. Magnesium Sulfate in Digitalis Toxicity.. Ann Intern Med. ;72:785. doi: 10.7326/0003-4819-72-5-785_1
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Published: Ann Intern Med. 1970;72(5):785.
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