L. M. Morrison, M.D., F.A.C.P.; J. J. Quilligan Jr., M.D.; K. Murata, M.D.; G. S. Bajwa, D.V.M.; S. Bernick, Ph.D.; P. G. Rucker, M.A.; L. Freeman, Ph.D.; B. H. Ershoff, Ph.D.
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Three acid mucopolysaccharides—heparin, chondroitin sulfate A and chondroitin sulfate C were tested for effectiveness against coronary and aortic atherosclerosis. Chondroitin sulfate A was found to be antiatherogenic in a series of monkeys, rats and rabbits; chondroitin sulfate C was found to be antiatherogenic in the two species tested, rats and rabbits. Heparin was not found to be antiatherogenic in monkeys. Chrondroitin sulfate A and C and heparin were found to be antithrombogenic in a series of dogs and rabbits, while chondroitin sulfate A and C were found to be orally both antiatherogenic and antithrombogenic in six consecutive experiments with rats.
Morrison LM, Quilligan JJ, Murata K, Bajwa GS, Bernick S, Rucker PG, et al. Prevention of Ischemic Heart Disease by Acid Mucopolysaccharides.. Ann Intern Med. ;72:786. doi: 10.7326/0003-4819-72-5-786_2
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Published: Ann Intern Med. 1970;72(5):786.
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