Sigmund R. Greenberg, M.D., F.A.C.P.; Sheldon I. Karabell, M.D.; G.A. Saade, M.D.
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Since hormonal information is transferred to the cell by the adenyl cyclase system with the production of 3′5′-cyclic adenosine monophosphate (AMP) (second messenger), end organ refractoriness in pseudohypoparathyroidism (PHP) can be demonstrated by a decreased 3′5′-cyclic AMP renal excretion after parathormone (PTH). Two sisters (11 and 8 years of age) were discovered to have PHP. J.D. (11 years) was admitted because of progressive extra-pyramidal signs, punctate calcification of the basal ganglia, short stature, Turner syndrome appearance, strabismus, absence of the fourth and fifth knuckles, hypocalcemia, and asthma. Her sister, R.A.D., (8 years) revealed somatic changes without symptoms. Both patients had
Greenberg SR, Karabell SI, Saade G. Pseudohypoparathyroidism (PHP)—A Disease of the Second Messenger 3′5′-CyCHc AMP.. Ann Intern Med. ;72:787–788. doi: 10.7326/0003-4819-72-5-787_5
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Published: Ann Intern Med. 1970;72(5):787-788.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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