Milton G. Crane, M.D., F.A.C.P.; John J. Harris, M.D., F.A.C.P.; William G. Winsor III, M.D.
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Twenty-one patients have been studied who developed hypertension (blood pressure 150/100) while taking oral contraceptives (OCP). Seventeen became normotensive (blood pressure 145/95) without antihypertensive medication in from 1 week to 12 months after stopping the drug. Average blood pressure before, during, and when the blood pressure was stabilized after stopping the OCP was 126/76, 190/110, and 130/91, respectively. In 11 patients tested the average plasma renin activity (PRA) (in response to sodium restriction and standing), the renin substrate (PRS), and aldosterone excretion rate (AES) were slightly to moderately elevated while the patients were on the OCP and decreased significantly (P
Crane MG, Harris JJ, Winsor WG. Conjugated Estrogens (CE) and Oral Contraceptives (OCP) in Relation to Renin Activity and Blood Pressure.. Ann Intern Med. ;72:789. doi: 10.7326/0003-4819-72-5-789_1
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Published: Ann Intern Med. 1970;72(5):789.
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