Donald O. Castell; Stephen M. Levine
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The physiologic sphincter mechanism at the distal end of the esophagus is believed to function as a barrier against the reflux of acid gastric contents into the esophagus. Recent studies have shown that the hormone gastrin has a profound effect on lower esophageal sphincter pressure, with marked increases in sphincter pressure resulting from injection of pentagastrin or after maneuvers known to cause release of endogenous gastrin.
Alkali in various forms is widely used in the treatment of heartburn, primarily to neutralize the acid gastric contents. The present study was performed to evaluate a possible additional effect of alkalinization of the
Castell DO, Levine SM. Effect of Gastric Alkalinization on Lower Esophageal Sphincter Pressure—A New Mechanism for Treatment of Heartburn with Antacids.. Ann Intern Med. ;72:792. doi: 10.7326/0003-4819-72-5-792_4
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Published: Ann Intern Med. 1970;72(5):792.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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