Alton I. Sutnick, M.D., F.A.C.P.; James J. Cerda, M.D.; Philip P. Toskes, M.D.; Veronica E. Coyne, M.D.; W. Thomas London, M.D., F.A.C.P.; Irving Millman, Ph.D.; Baruch S. Blumberg, M.D., F.A.C.P.
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The association of Australia antigen (Au(1)) with viral hepatitis led to the hypothesis that it is a hepatitis virus. We have published clinical, epidemiologic, immunologic, and electron microscopic studies supporting this hypothesis. Au(1) is transient in blood of acute hepatitis patients; it is markedly prolonged or persistent in patients with Down's syndrome (30%), leukemia (10%), lepromatous leprosy (10%), and chronic hemodialysis patients (8 of 9). It occurs in 5 to 20% of asymptomatic people in the tropics where family studies indicate an inherited trait causing susceptibility to persistent infection with Au(1). Au(1) persists in 0.1% of the normal U.S. population;
Sutnick AI, Cerda JJ, Toskes PP, Coyne VE, London WT, Millman I, et al. Acute and Persistent Australia Antigen in Drug Users.. Ann Intern Med. ;72:793. doi: 10.7326/0003-4819-72-5-793_4
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Published: Ann Intern Med. 1970;72(5):793.
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