Alton I. Sutnick, M.D., F.A.C.P.; James J. Cerda, M.D.; Philip P. Toskes, M.D.; Veronica E. Coyne, M.D.; W. Thomas London, M.D., F.A.C.P.; Irving Millman, Ph.D.; Baruch S. Blumberg, M.D., F.A.C.P.
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The association of Australia antigen (Au(1)) with viral hepatitis led to the hypothesis that it is a hepatitis virus. We have published clinical, epidemiologic, immunologic, and electron microscopic studies supporting this hypothesis. Au(1) is transient in blood of acute hepatitis patients; it is markedly prolonged or persistent in patients with Down's syndrome (30%), leukemia (10%), lepromatous leprosy (10%), and chronic hemodialysis patients (8 of 9). It occurs in 5 to 20% of asymptomatic people in the tropics where family studies indicate an inherited trait causing susceptibility to persistent infection with Au(1). Au(1) persists in 0.1% of the normal U.S. population;
Alton I. Sutnick, James J. Cerda, Philip P. Toskes, Veronica E. Coyne, W. Thomas London, Irving Millman, et al. Acute and Persistent Australia Antigen in Drug Users.. Ann Intern Med. 1970;72:793. doi: 10.7326/0003-4819-72-5-793_4
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Published: Ann Intern Med. 1970;72(5):793.
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