John H. Frenster, M.D.; R. Brent Archibald, B.S.
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Although the blood lymphocytes of patients with Hodgkin's disease may display a reduced in vitro response to antigens and phytohemagglutinin, lymphocytic infiltration of Hodgkin's disease lymph nodes does correlate positively with a favorable prognosis (Cancer 22:487, 1968). Such infiltration is thought to represent a host immune response to the neoplastic Reed-Sternberg cells and their precursors (J Nat Cancer Inst 39:557, 1967).
Lymph node biopsies positive for Reed-Sternberg cells from previously-untreated patients were examined by electron microscopy. Reed-Sternberg cells (class 5) and their precursor cells (classes 2 to 4) were identified and were graded for ultrastructural toxic changes (A = none;
Frenster JH, Brent Archibald R. Interactions of Lymphocytes With Reed-Sternberg Cells Within Hodgkins Disease Lymph Nodes.. Ann Intern Med. ;72:794. doi: 10.7326/0003-4819-72-5-794_2
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Published: Ann Intern Med. 1970;72(5):794.
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