Robert J. Jacobson, M.B., B.Ch.; Dudley P. Jackson, M.D., F.A.C.P.
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Fragmentation of red blood cells has been reported in association with disseminated intravascular coagulation. The proportion of red blood cells showing morphologic alterations associated with fragmentation was graded from 0 to III in smears of peripheral blood from 40 patients with defibrination. All patients had hypofibrinogenemia (mean, 70 mg/100 ml), and most had thrombocytopenia, but none had hypertension. Smears from 23 (58%) patients revealed no evidence of microangiopathic hemolytic anemia. The diagnoses in these patients were: 10 with abruptio placenta; 6 with carcinoma; 4 with intrauterine fetal death; and 1 each with septicemia, purpura fulminans, and Rocky Mountain spotted fever.
Jacobson RJ, Jackson DP. Microangiopathic Hemolytic Anemia in Defibrination Syndromes.. Ann Intern Med. ;72:794. doi: 10.7326/0003-4819-72-5-794_3
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Published: Ann Intern Med. 1970;72(5):794.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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